HitPredict

Interactor 1: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Interactor 2: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	35140242, 18552123, 15604093, 21292004
Identification Methods	proximity labelling technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 474 Hs			1 2063
+	Hs
		587169 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		369612 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		782706 HNF4A_HUMAN (1-474): 0: 542: 100.00		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		782596 HNF4A_HUMAN (1-474): 0: 542: 100.00		ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54
+	Hs
		782677 HNF4A_HUMAN (1-474): 0: 542: 100.00		CHD7_HUMAN (169-662): 2.63e-11: 71.8: 12.93
+	Hs
		782595 HNF4A_HUMAN (1-474): 0: 542: 100.00		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23
+	Hs
		782640 HNF4A_HUMAN (1-474): 0: 542: 100.00		MINT_HUMAN (1100-2062): 1.16e-09: 66.2: 9.24
+	Hs
		587211 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		818890 RXRG_HUMAN (3-378): 6.44e-125: 373: 35.57		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		370417 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		TARA_HUMAN (168-1726): 1.14e-25: 118: 9.69
+	Hs
		368927 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		MUC1_HUMAN (159-883): 4.81e-23: 110: 10.47
+	Hs
		370824 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		500380 RARB_HUMAN (10-424): 2.37e-114: 345: 25.23		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		369171 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		369607 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Mm
		99856 ESR1_MOUSE (10-432): 1.18e-112: 346: 21.58		F6M2J9_MOUSE (339-1212): 9.08e-12: 72.9: 10.93
+	Hs
		370607 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		CHD7_HUMAN (169-662): 2.63e-11: 71.8: 12.93
+	Hs
		370040 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23
+	Hs
		370263 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		MINT_HUMAN (1100-2062): 1.16e-09: 66.2: 9.24
+	Hs
		370728 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		SRRM2_HUMAN (1328-2061): 5.87e-09: 63.7: 10.47