HitPredict

Interactor 1: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Interactor 2: REQU (Q92785)
Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)
Gene: DPF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 474 Hs			1 391
+	Hs
		782607 HNF4A_HUMAN (1-474): 0: 542: 100.00		DPF1_HUMAN (1-385): 1.2e-87: 272: 56.25
+	Hs
		782695 HNF4A_HUMAN (1-474): 0: 542: 100.00		TRI33_HUMAN (6-389): 8.72e-52: 188: 12.66
+	Hs
		782534 HNF4A_HUMAN (1-474): 0: 542: 100.00		CHD3_HUMAN (43-382): 1.44e-49: 181: 13.23
+	Hs
		782694 HNF4A_HUMAN (1-474): 0: 542: 100.00		KMT2B_HUMAN (109-383): 2.28e-41: 157: 19.00
+	Hs
		170289 HNF4A_HUMAN (1-474): 0: 542: 100.00		TIF1A_HUMAN (25-391): 1.7e-32: 131: 14.06
+	Hs
		782600 HNF4A_HUMAN (1-474): 0: 542: 100.00		PHF10_HUMAN (226-384): 1.03e-31: 127: 35.19
+	Hs
		152605 HNF4A_HUMAN (1-474): 0: 542: 100.00		KMT2D_HUMAN (241-382): 8.36e-23: 102: 30.77
+	Hs
		782595 HNF4A_HUMAN (1-474): 0: 542: 100.00		KMT2C_HUMAN (266-376): 2.95e-09: 61.3: 22.22
+	Hs
		1055258 HNF4G_HUMAN (52-456): 5.67e-137: 402: 73.58		NSD1_HUMAN (101-375): 8.5e-35: 138: 17.97
+	Mm
		659684 RXRA_MOUSE (5-377): 8.55e-126: 375: 37.01		TIF1A_MOUSE (25-391): 8.08e-37: 144: 14.32
+	Mm
		93747 RXRA_MOUSE (5-377): 8.55e-126: 375: 37.01		E9QAE4_MOUSE (101-375): 1.64e-35: 140: 17.65
+	Hs
		587193 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		NSD1_HUMAN (101-375): 8.5e-35: 138: 17.97
+	Hs
		369621 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Hs
		170251 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		TIF1A_HUMAN (25-391): 1.7e-32: 131: 14.06
+	Mm
		587105 ESR1_MOUSE (10-432): 1.18e-112: 346: 21.58		TIF1A_MOUSE (25-391): 8.08e-37: 144: 14.32
+	Hs
		490110 COT1_HUMAN (22-386): 4.95e-116: 349: 33.60		NSD1_HUMAN (101-375): 8.5e-35: 138: 17.97
+	Hs
		369449 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		KMT2A_HUMAN (80-388): 8.66e-36: 141: 14.38
+	Hs
		170202 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		TIF1A_HUMAN (25-391): 1.7e-32: 131: 14.06
+	Hs
		152573 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		KMT2D_HUMAN (241-382): 8.36e-23: 102: 30.77
+	Hs
		369044 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		KDM5A_HUMAN (309-375): 1.26e-20: 96.4: 35.82