HitPredict - High confidence protein-protein interactions

Interactor 1: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Interactor 2: PROX1 (Q92786)
Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1)
Gene: PROX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.615

Property	Details
Experiments	15604093, 16488887
Identification Methods	two hybrid, anti bait coimmunoprecipitation, lexa b52 complementation, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding and 11 others more... GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0006366 - transcription by RNA polymerase II GO:0008285 - negative regulation of cell population proliferation GO:0042752 - regulation of circadian rhythm GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	474
Hs

1	737

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Last updated: 15 Jul 2024