HitPredict

Interactor 1: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 474 Hs			1 3159
+	Hs
		370225 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		229273 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		229452 ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		587181 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		CHD9_HUMAN (1565-2538): 3.24e-144: 509: 13.41
+	Hs
		369729 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		CHD9_HUMAN (1565-2538): 3.24e-144: 509: 13.41
+	Hs
		370482 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Hs
		370686 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		INO80_HUMAN (1754-2150): 2.56e-83: 307: 25.38
+	Hs
		782578 HNF4A_HUMAN (1-474): 0: 542: 100.00		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		782677 HNF4A_HUMAN (1-474): 0: 542: 100.00		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		782503 HNF4A_HUMAN (1-474): 0: 542: 100.00		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		782504 HNF4A_HUMAN (1-474): 0: 542: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		622838 COT2_HUMAN (21-384): 1.62e-113: 342: 33.15		SMRCD_HUMAN (1895-2052): 1.85e-24: 115: 38.27
+	Hs
		587141 RXRA_HUMAN (5-377): 4.91e-125: 373: 37.01		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		370607 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		369213 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		369214 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		611401 NR4A1_HUMAN (11-380): 1.23e-98: 310: 25.00		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		846832 ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		611402 NR4A1_HUMAN (11-380): 1.23e-98: 310: 25.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		847036 ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17