HitPredict

Interactor 1: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Interactor 2: MED17 (Q9NVC6)
Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)
Gene: MED17

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12101254
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 474 Hs			1 651
+	Hs
		370538 ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Hs
		1269737 ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Mm
		1142698 ERR2_MOUSE (9-375): 1.5e-99: 307: 27.37		MED17_MOUSE (1-651): 0: 1033: 95.70
+	Hs
		500448 THA_HUMAN (20-436): 4.49e-97: 302: 23.03		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Dm
		589670 USP_DROME (49-348): 8.94e-45: 165: 30.24		MED17_DROME (6-647): 0: 849: 42.19