HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: UBS3A (P57075)
Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
Gene: UBASH3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 661
+	Hs
		782811 CSK_HUMAN (1-450): 0: 543: 100.00		UBS3B_HUMAN (1-655): 0: 904: 43.07
+	Hs
		337511 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		UBS3B_HUMAN (1-655): 0: 904: 43.07
+	Hs
		69209 A9UF07_HUMAN (5-447): 2.25e-159: 494: 37.83		UBS3B_HUMAN (1-655): 0: 904: 43.07
+	Hs
		782767 CSK_HUMAN (1-450): 0: 543: 100.00		GRB2_HUMAN (245-341): 1.31e-22: 98.4: 25.25
+	Hs
		433354 YES_HUMAN (12-442): 5.99e-170: 490: 37.30		LASP1_HUMAN (163-337): 3.87e-36: 138: 17.11
+	Hs
		235462 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		VINEX_HUMAN (202-339): 5.67e-28: 121: 22.86
+	Hs
		235483 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		VINEX_HUMAN (202-339): 5.67e-28: 121: 22.86
+	Hs
		298944 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		SRBS2_HUMAN (200-339): 2.17e-23: 107: 22.37
+	Hs
		337548 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		SRBS1_HUMAN (145-339): 1.51e-20: 99.1: 21.46
+	Hs
		337418 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		GRB2_HUMAN (245-341): 1.31e-22: 98.4: 25.25
+	Hs
		69206 A9UF07_HUMAN (5-447): 2.25e-159: 494: 37.83		GRB2_HUMAN (245-341): 1.31e-22: 98.4: 25.25
+	Hs
		298959 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		SRBS2_HUMAN (200-339): 2.17e-23: 107: 22.37
+	Hs
		523130 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		SRBS1_HUMAN (145-339): 1.51e-20: 99.1: 21.46
+	Hs
		522887 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		GRB2_HUMAN (245-341): 1.31e-22: 98.4: 25.25
+	Mm
		763393 FYN_MOUSE (12-442): 1.69e-170: 491: 36.77		GRB2_MOUSE (245-341): 1.89e-22: 98: 24.24
+	Hs
		789054 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		GRB2_HUMAN (245-341): 1.31e-22: 98.4: 25.25
+	Hs
		337608 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		CD2AP_HUMAN (155-343): 1.01e-12: 73.3: 18.75
+	Hs
		412426 FYN_HUMAN (12-442): 1.26e-170: 491: 36.77		CD2AP_HUMAN (155-343): 1.01e-12: 73.3: 18.75
+	Hs
		433859 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		SH3R1_HUMAN (194-337): 1.29e-18: 92.6: 18.42
+	Hs
		442898 HCK_HUMAN (3-445): 6.38e-167: 481: 36.32		CD2AP_HUMAN (155-343): 1.01e-12: 73.3: 18.75