HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	31980649, 21706016, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0019903 - protein phosphatase binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 217
+	Hs
		337418 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411626 CSK_HUMAN (1-450): 0: 543: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		782749 CSK_HUMAN (1-450): 0: 543: 100.00		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Mm
		782841 CSK_MOUSE (1-450): 0: 543: 99.11		CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57
+	Hs
		412066 CSK_HUMAN (1-450): 0: 543: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Rn
		693648 CSK_RAT (1-450): 0: 543: 98.44		SRC_RAT (117-215): 2.55e-11: 64.2: 20.79
+	Hs
		522833 CSK_HUMAN (1-450): 0: 543: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		782751 CSK_HUMAN (1-450): 0: 543: 100.00		FRK_HUMAN (150-212): 6.98e-11: 62.7: 27.78
+	Dm
		337641 ABL_DROME (5-447): 1.98e-163: 502: 38.11		ABL_DROME (4-135): 1e-22: 97.4: 37.68
+	Mm
		337637 ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83		NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14
+	Mm
		337615 ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		337337 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337293 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		337384 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		337333 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		337307 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		337315 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Gg
		337663 SRC_CHICK (12-442): 7.32e-173: 496: 39.78		SRC_CHICK (81-215): 7.55e-12: 65.7: 16.08
+	Hs
		337329 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		275157 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62