HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12473651
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070373 - negative regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 770
+	Hs
		412132 FYN_HUMAN (12-442): 1.26e-170: 491: 36.77		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		522909 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		454823 FGR_HUMAN (12-442): 4.47e-165: 476: 38.43		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		411643 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20
+	Dm
		337651 ABL_DROME (5-447): 1.98e-163: 502: 38.11		DAB_DROME (42-732): 1.16e-36: 151: 22.46
+	Mm
		763385 FYN_MOUSE (12-442): 1.69e-170: 491: 36.77		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Mm
		956225 YES_MOUSE (12-442): 6.97e-170: 489: 37.08		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Mm
		403429 SRC_MOUSE (12-442): 1.93e-169: 488: 39.55		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Hs
		411911 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		NUMBL_HUMAN (18-585): 6.55e-41: 161: 13.54
+	Hs
		433649 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20
+	Hs
		253524 FYN_HUMAN (12-442): 1.26e-170: 491: 36.77		CAPON_HUMAN (19-299): 8.52e-35: 141: 13.91
+	Hs
		253523 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		CAPON_HUMAN (19-299): 8.52e-35: 141: 13.91
+	Mm
		403451 SRC_MOUSE (12-442): 1.93e-169: 488: 39.55		SHC2_MOUSE (6-368): 1.03e-33: 138: 11.97
+	Hs
		434112 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		NUMBL_HUMAN (18-585): 6.55e-41: 161: 13.54
+	Hs
		297808 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		K0754_HUMAN (247-770): 7.02e-32: 136: 10.75
+	Hs
		337335 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		MUC1_HUMAN (320-766): 7.89e-22: 103: 14.16
+	Hs
		522749 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		MUC1_HUMAN (320-766): 7.89e-22: 103: 14.16
+	Hs
		411582 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		MUC1_HUMAN (320-766): 7.89e-22: 103: 14.16
+	Hs
		203198 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Hs
		433560 LYN_HUMAN (4-445): 3.75e-160: 463: 37.12		MUC1_HUMAN (320-766): 7.89e-22: 103: 14.16