HitPredict

Interactor 1: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Interactor 2: FHL2 (Q14192)
Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)
Gene: FHL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	18255255
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 450 Hs			1 279
+	Hs
		200163 CSK_HUMAN (1-450): 0: 543: 100.00		TGFI1_HUMAN (3-218): 4.81e-69: 222: 26.39
+	Hs
		442827 HCK_HUMAN (3-445): 6.38e-167: 481: 36.32		FHL2_HUMAN (1-279): 4.64e-77: 237: 100.00
+	Hs
		782755 CSK_HUMAN (1-450): 0: 543: 100.00		PAXI_HUMAN (187-279): 1.89e-18: 86.9: 23.53
+	Hs
		442845 HCK_HUMAN (3-445): 6.38e-167: 481: 36.32		FHL5_HUMAN (65-279): 3.56e-38: 137: 31.34
+	Hs
		254384 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		LDB3_HUMAN (2-92): 6.25e-30: 120: 28.57
+	Mm
		337635 ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83		PAXI_MOUSE (187-279): 1.17e-18: 87.3: 23.53
+	Hs
		337395 ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83		PAXI_HUMAN (187-279): 1.89e-18: 86.9: 23.53
+	Hs
		412085 FYN_HUMAN (12-442): 1.26e-170: 491: 36.77		PAXI_HUMAN (187-279): 1.89e-18: 86.9: 23.53
+	Hs
		522857 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		PAXI_HUMAN (187-279): 1.89e-18: 86.9: 23.53
+	Hs
		433288 YES_HUMAN (12-442): 5.99e-170: 490: 37.30		PAXI_HUMAN (187-279): 1.89e-18: 86.9: 23.53
+	Mm
		403454 SRC_MOUSE (12-442): 1.93e-169: 488: 39.55		PAXI_MOUSE (187-279): 1.17e-18: 87.3: 23.53
+	Hs
		111447 J3QRU1_HUMAN (12-442): 7.07e-170: 490: 37.30		PDLI7_HUMAN (3-163): 2e-17: 83.6: 29.19
+	Hs
		433484 YES_HUMAN (12-442): 5.99e-170: 490: 37.30		PDLI7_HUMAN (3-163): 2e-17: 83.6: 29.19
+	Hs
		411641 LCK_HUMAN (5-443): 1.95e-168: 485: 38.55		PAXI_HUMAN (187-279): 1.89e-18: 86.9: 23.53
+	Hs
		789046 ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33		PAXI_HUMAN (187-279): 1.89e-18: 86.9: 23.53
+	Hs
		442793 HCK_HUMAN (3-445): 6.38e-167: 481: 36.32		PAXI_HUMAN (187-279): 1.89e-18: 86.9: 23.53
+	Ce
		107570 ABL1_CAEEL (12-447): 3.52e-156: 475: 38.56		G5EFG1_CAEEL (3-150): 1.53e-19: 90.1: 30.67
+	Ce
		106914 ABL1_CAEEL (12-447): 3.52e-156: 475: 38.56		G5EEL1_CAEEL (3-150): 2.09e-19: 89.7: 30.67
+	Ce
		107567 SRC2_CAEEL (14-443): 8.09e-162: 468: 36.96		G5EFG1_CAEEL (3-150): 1.53e-19: 90.1: 30.67
+	Hs
		522967 SRC_HUMAN (12-442): 8.48e-171: 491: 39.33		FHL1_HUMAN (183-279): 8.68e-11: 63.4: 30.28