HitPredict

Interactor 1: M3K8 (P41279)
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Gene: MAP3K8

Interactor 2: M3K8 (P41279)
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Gene: MAP3K8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 19754427, 24265246, 14743216
Identification Methods protein kinase assay, tandem affinity purification
Interaction Type phosphorylation reaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
and 4 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 467
Hs

1 467
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024