HitPredict

Interactor 1: CCR2 (P41597)
C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)
Gene: CCR2

Interactor 2: CCL8 (P80075)
C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]
Gene: CCL8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 9195948, 9115216
Identification Methods biochemical, competition binding
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~IL8
Common GO terms GO:0002548 - monocyte chemotaxis
GO:0006874 - intracellular calcium ion homeostasis
GO:0006935 - chemotaxis
GO:0006954 - inflammatory response
GO:0031727 - CCR2 chemokine receptor binding
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 374
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1 99
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Last updated: 15 Jul 2024