HitPredict

Interactor 1: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Interactor 2: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007015 - actin filament organization GO:0070062 - extracellular exosome GO:1903078 - positive regulation of protein localization to plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 596 Hs			1 191
+	Hs
		783972 KPCI_HUMAN (1-596): 0: 706: 100.00		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		545242 KPCI_HUMAN (1-596): 0: 706: 100.00		RAC2_HUMAN (1-191): 1.28e-78: 234: 71.35
+	Hs
		783964 KPCI_HUMAN (1-596): 0: 706: 100.00		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		783965 KPCI_HUMAN (1-596): 0: 706: 100.00		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		436188 KPCI_HUMAN (1-596): 0: 706: 100.00		RHOC_HUMAN (5-191): 8.34e-77: 230: 56.15
+	Mm
		892726 KPCI_MOUSE (1-596): 0: 700: 98.32		CDC42_MOUSE (1-191): 1.3e-78: 234: 60.73
+	Hs
		783963 KPCI_HUMAN (1-596): 0: 706: 100.00		RAC3_HUMAN (1-177): 1.67e-75: 226: 72.88
+	Hs
		564438 KPCI_HUMAN (1-596): 0: 706: 100.00		RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84
+	Hs
		925221 KPCZ_HUMAN (15-596): 0: 631: 70.34		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Dm
		54649 APKC_DROME (1-596): 0: 637: 65.67		CDC42_DROME (1-191): 1.78e-77: 231: 60.21
+	Hs
		893928 KPCZ_HUMAN (15-596): 0: 631: 70.34		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		900405 KPCZ_HUMAN (15-596): 0: 631: 70.34		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Rn
		448411 KPCD_RAT (93-587): 4.48e-177: 518: 35.74		RAC1_RAT (1-191): 3.6e-82: 243: 71.88
+	Hs
		900406 KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52		RHOA_HUMAN (5-191): 1.26e-78: 234: 55.62
+	Hs
		436269 KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52		RHOC_HUMAN (5-191): 8.34e-77: 230: 56.15
+	Hs
		681775 AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88
+	Hs
		564425 AKT2_HUMAN (187-586): 9.51e-152: 447: 39.36		RHOQ_HUMAN (4-189): 5.74e-73: 220: 56.84
+	Hs
		616691 KS6B1_HUMAN (215-594): 1.3e-145: 432: 35.94		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		270390 KS6A5_HUMAN (62-540): 2.04e-118: 371: 17.96		CDC42_HUMAN (1-191): 1.3e-78: 234: 60.73
+	Hs
		850632 KS6A3_HUMAN (122-543): 1.57e-104: 333: 20.47		RAC1_HUMAN (1-191): 3.6e-82: 243: 71.88