HitPredict

Interactor 1: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.987

Property	Details
Experiments	26187466, 31980649, 9566925, 14676191, 12813044, 20808283, 26043024, 29551772, 30581152, 32296183, 34079125, 33545068, 20562859, 16861740, unassigned1304, unassigned2173
Identification Methods	unspecified method, affinity chromatography technology, two hybrid, fluorescent resonance energy transfer, pull down, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array and 1 others more... validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PB1~PB1, PB1~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0070062 - extracellular exosome GO:1903078 - positive regulation of protein localization to plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 596 Hs			1 440
+	Rn
		94344 KPCI_RAT (1-596): 0: 705: 98.66		SQSTM_RAT (1-440): 0: 746: 90.95
+	Hs
		983828 KPCZ_HUMAN (15-596): 0: 631: 70.34		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Rn
		139612 KPCZ_RAT (1-596): 0: 630: 69.37		SQSTM_RAT (1-440): 0: 746: 90.95
+	Mm
		973811 KPCZ_MOUSE (1-596): 0: 625: 69.04		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Rn
		139624 KPCL_RAT (73-589): 0: 545: 38.69		SQSTM_RAT (1-440): 0: 746: 90.95
+	Hs
		984491 KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Rn
		139610 KPCD_RAT (93-587): 4.48e-177: 518: 35.74		SQSTM_RAT (1-440): 0: 746: 90.95
+	Rn
		139611 KPCE_RAT (43-590): 2.47e-175: 516: 35.57		SQSTM_RAT (1-440): 0: 746: 90.95
+	Mm
		661009 KPCD_MOUSE (93-589): 2.66e-177: 519: 35.40		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Hs
		616709 KS6B1_HUMAN (215-594): 1.3e-145: 432: 35.94		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Rn
		139620 KPCB_RAT (111-229): 6.26e-18: 89.6: 21.28		SQSTM_RAT (1-440): 0: 746: 90.95
+	Rn
		139619 KPCG_RAT (126-190): 1.85e-12: 72.4: 43.08		SQSTM_RAT (1-440): 0: 746: 90.95
+	Hs
		784009 KPCI_HUMAN (1-596): 0: 706: 100.00		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78
+	Dm
		54642 APKC_DROME (1-596): 0: 637: 65.67		REF2P_DROME (107-170): 7.35e-20: 94: 36.92