HitPredict

Interactor 1: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0007015 - actin filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 596 Hs			1 191
+	Hs
		436188 KPCI_HUMAN (1-596): 0: 706: 100.00		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		783971 KPCI_HUMAN (1-596): 0: 706: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		783972 KPCI_HUMAN (1-596): 0: 706: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		564438 KPCI_HUMAN (1-596): 0: 706: 100.00		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		783964 KPCI_HUMAN (1-596): 0: 706: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545242 KPCI_HUMAN (1-596): 0: 706: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		783963 KPCI_HUMAN (1-596): 0: 706: 100.00		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		783983 KPCI_HUMAN (1-596): 0: 706: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Mm
		892726 KPCI_MOUSE (1-596): 0: 700: 98.32		CDC42_MOUSE (2-181): 1.52e-73: 221: 42.25
+	Hs
		783965 KPCI_HUMAN (1-596): 0: 706: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		925221 KPCZ_HUMAN (15-596): 0: 631: 70.34		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		893928 KPCZ_HUMAN (15-596): 0: 631: 70.34		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Dm
		54649 APKC_DROME (1-596): 0: 637: 65.67		CDC42_DROME (2-191): 7.23e-71: 214: 40.10
+	Hs
		900405 KPCZ_HUMAN (15-596): 0: 631: 70.34		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		623871 KPCL_HUMAN (73-589): 0: 543: 38.49		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		436269 KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		915625 KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Rn
		448411 KPCD_RAT (93-587): 4.48e-177: 518: 35.74		RAC1_RAT (2-191): 2.63e-75: 226: 39.09
+	Hs
		900406 KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		564425 AKT2_HUMAN (187-586): 9.51e-152: 447: 39.36		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49