HitPredict

Interactor 1: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Interactor 2: KIBRA (Q8IX03)
Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1)
Gene: WWC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	28720576, 33961781, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~C2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016477 - cell migration
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 596 Hs			1 1113
+	Hs
		983870 KPCZ_HUMAN (15-596): 0: 631: 70.34		KIBRA_HUMAN (1-1113): 0: 842: 100.00
+	Dm
		54663 APKC_DROME (1-596): 0: 637: 65.67		KIBRA_DROME (4-1111): 0: 595: 31.01
+	Hs
		566424 KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37		KIBRA_HUMAN (1-1113): 0: 842: 100.00
+	Hs
		566415 KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37		WWC2_HUMAN (5-1113): 0: 779: 48.44
+	Hs
		566504 KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37		WWC3_HUMAN (3-1113): 0: 742: 41.22
+	Hs
		784093 KPCI_HUMAN (1-596): 0: 706: 100.00		SMUF1_HUMAN (674-1092): 5.34e-17: 88.3: 12.33
+	Dm
		54672 APKC_DROME (1-596): 0: 637: 65.67		Q9W2L2_DROME (5-90): 3.25e-35: 148: 43.02
+	Hs
		1299664 AKT3_HUMAN (120-586): 3.11e-152: 448: 33.19		NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09
+	Hs
		681988 AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86		NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09
+	Hs
		1299657 KS6B2_HUMAN (245-592): 8.21e-147: 434: 38.64		NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09
+	Xl
		1151478 SGK1A_XENLA (183-588): 2.98e-146: 431: 35.92		Q6GMD5_XENLA (669-807): 2.74e-33: 141: 15.17
+	Hs
		808324 AKT3_HUMAN (120-586): 3.11e-152: 448: 33.19		NEDD4_HUMAN (26-161): 2.24e-09: 64: 21.32
+	Hs
		681731 AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86		NEDD4_HUMAN (26-161): 2.24e-09: 64: 21.32
+	Hs
		616684 KS6B1_HUMAN (215-594): 1.3e-145: 432: 35.94		NEDD4_HUMAN (26-161): 2.24e-09: 64: 21.32
+	Hs
		808054 KS6A3_HUMAN (122-543): 1.57e-104: 333: 20.47		NEDD4_HUMAN (26-161): 2.24e-09: 64: 21.32
+	Hs
		566492 KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37		WWOX_HUMAN (5-113): 1.68e-31: 130: 29.46
+	Hs
		566484 KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37		SMUF1_HUMAN (674-1092): 5.34e-17: 88.3: 12.33
+	Hs
		397181 KPCG_HUMAN (107-190): 1.32e-12: 72.8: 39.29		SMUF1_HUMAN (674-1092): 5.34e-17: 88.3: 12.33