HitPredict

Interactor 1: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Interactor 2: MARK4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Gene: MARK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.63 1.00 0.799

The method score is based on:

Property Details
Experiments 26346160, 14676191
Identification Methods enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Pkinase, PB1~Pkinase, KA1~Pkinase, Pkinase~Pkinase, Pkinase~UBA, Pkinase~Pkinase_C
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006468 - protein phosphorylation
GO:0015630 - microtubule cytoskeleton
and 2 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 596
Hs

1 752
+ Xl
+ Hs
+ Dm
+ Hs
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+ Hs
+ Hs
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+ Dm
+ Hs

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Last updated: 15 Jul 2024