HitPredict

Interactor 1: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PH, PH~Pkinase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 596 Hs			1 779
+	Hs
		983922 KPCZ_HUMAN (15-596): 0: 631: 70.34		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		623884 KPCL_HUMAN (73-589): 0: 543: 38.49		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		984534 KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682210 AKT2_HUMAN (187-586): 9.51e-152: 447: 39.36		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682023 AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		784000 KPCI_HUMAN (1-596): 0: 706: 100.00		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		270445 KS6A5_HUMAN (62-540): 2.04e-118: 371: 17.96		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		299245 KPCI_HUMAN (1-596): 0: 706: 100.00		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69
+	Dm
		54650 APKC_DROME (1-596): 0: 637: 65.67		SIF2_DROME (7-634): 3.14e-45: 178: 12.50
+	Hs
		850712 KS6A3_HUMAN (122-543): 1.57e-104: 333: 20.47		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		983819 KPCZ_HUMAN (15-596): 0: 631: 70.34		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		299257 KPCZ_HUMAN (15-596): 0: 631: 70.34		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69
+	Hs
		969077 KPCE_HUMAN (43-590): 1.72e-177: 521: 36.23		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		984488 KPCD_HUMAN (93-591): 2.71e-176: 516: 34.52		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		681831 AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Rn
		1144020 AKT3_RAT (120-586): 6.07e-151: 444: 33.19		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		408682 KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		566481 KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		408612 KPCB_HUMAN (111-229): 6.31e-18: 89.6: 21.28		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		566377 KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28