HitPredict

Interactor 1: PBX1 (P41778)
Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1)
Gene: PBX1

Interactor 2: Q9QX99 (Q9QX99)
T-cell leukemia, homeobox 1 (Transcription factor)
Gene: Tlx1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeodomain
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 430 Mm			1 333
+	Hs
		679067 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		TLX1_HUMAN (1-333): 1.1e-60: 199: 93.99
+	Hs
		447226 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		HXB5_HUMAN (53-276): 3.98e-41: 146: 23.93
+	Mm
		685401 PBX1_MOUSE (1-430): 1.17e-150: 436: 100.00		HXC5_MOUSE (72-268): 1.11e-35: 130: 25.00
+	Hs
		773059 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		PDX1_HUMAN (82-284): 4.58e-34: 128: 26.67
+	Hs
		174011 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		SHOX_HUMAN (186-302): 1.45e-33: 127: 24.79
+	Mm
		446929 PBX1_MOUSE (1-430): 1.17e-150: 436: 100.00		HXB6_MOUSE (66-273): 1.17e-33: 125: 25.94
+	Hs
		678849 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		HXA9_HUMAN (18-270): 7.15e-33: 124: 19.25
+	Hs
		453053 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		HXB7_HUMAN (42-274): 6.72e-32: 120: 23.61
+	Mm
		453070 PBX1_MOUSE (1-430): 1.17e-150: 436: 100.00		HXA9_MOUSE (18-270): 3.18e-31: 120: 19.32
+	Hs
		238100 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		LMX1B_HUMAN (162-333): 7.39e-30: 119: 18.04
+	Mm
		446923 PBX1_MOUSE (1-430): 1.17e-150: 436: 100.00		HXA5_MOUSE (16-279): 5.27e-31: 119: 21.86
+	Mm
		82704 PBX1_MOUSE (1-430): 1.17e-150: 436: 100.00		B9EHK7_MOUSE (36-278): 4.19e-30: 118: 20.73
+	Mm
		446928 PBX1_MOUSE (1-430): 1.17e-150: 436: 100.00		HXA1_MOUSE (36-278): 1.08e-29: 117: 20.73
+	Hs
		446865 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		HXD4_HUMAN (65-303): 8.7e-30: 116: 23.43
+	Mm
		447606 PBX1_MOUSE (1-430): 1.17e-150: 436: 100.00		HXA6_MOUSE (54-282): 3.03e-30: 116: 18.67
+	Mm
		496123 PBX1_MOUSE (1-430): 1.17e-150: 436: 100.00		HXD4_MOUSE (62-290): 1.03e-29: 115: 22.71
+	Hs
		567797 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		HXB8_HUMAN (80-290): 1.14e-29: 115: 19.54
+	Hs
		773062 PBX1_HUMAN (1-430): 1.17e-150: 436: 100.00		HXC5_HUMAN (53-270): 8.57e-30: 115: 22.02
+	Hs
		238102 PBX3_HUMAN (1-430): 1.06e-143: 418: 81.32		LMX1B_HUMAN (162-333): 7.39e-30: 119: 18.04
+	Hs
		567798 PBX3_HUMAN (1-430): 1.06e-143: 418: 81.32		HXB8_HUMAN (80-290): 1.14e-29: 115: 19.54