HitPredict

Interactor 1: PRS8 (P41836)
26S proteasome regulatory subunit 8 homolog (Protein let1)
Gene: let1

Interactor 2: RPN11 (P41878)
26S proteasome regulatory subunit rpn11 (Protein pad1)
Gene: RPN11

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20838651
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~Prot_ATP_ID_OB
Common GO terms	GO:0005634 - nucleus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 403 Sp			1 308
+	Sp
		251475 PRS10_SCHPO (21-401): 7.3e-156: 446: 45.29		RPN11_SCHPO (1-308): 4.2e-107: 316: 100.00
+	Dm
		820501 PRS4_DROME (7-395): 1.05e-135: 397: 44.22		PSDE_DROME (1-308): 7.51e-111: 325: 67.86
+	At
		1339598 PRS4A_ARATH (7-393): 5.26e-135: 395: 45.22		PSDE_ARATH (1-308): 1.67e-110: 324: 69.81
+	Hs
		130831 PRS4_HUMAN (9-395): 9.52e-136: 397: 45.48		PSDE_HUMAN (19-308): 2.23e-105: 311: 70.35
+	Hs
		130788 PRS6B_HUMAN (10-396): 9.6e-118: 350: 42.12		PSDE_HUMAN (19-308): 2.23e-105: 311: 70.35
+	Dm
		1181024 Q7KMQ0_DROME (80-388): 3.53e-111: 334: 55.34		PSDE_DROME (1-308): 7.51e-111: 325: 67.86
+	Hs
		130770 PRS7_HUMAN (80-388): 2.37e-112: 337: 56.31		PSDE_HUMAN (19-308): 2.23e-105: 311: 70.35
+	Sc
		797537 PRS8_YEAST (6-403): 7.89e-121: 358: 76.38		RPN11_YEAST (1-308): 6.26e-93: 279: 64.29
+	Sc
		703920 PRS7_YEAST (80-389): 1.94e-109: 331: 55.81		RPN11_YEAST (1-308): 6.26e-93: 279: 64.29
+	Dm
		640769 PRS4_DROME (7-395): 1.05e-135: 397: 44.22		PSMD7_DROME (26-307): 6.44e-60: 196: 19.05
+	Hs
		849176 PRS4_HUMAN (9-395): 9.52e-136: 397: 45.48		PSMD7_HUMAN (27-307): 4.23e-59: 193: 19.80
+	At
		1320084 PRS4A_ARATH (7-393): 5.26e-135: 395: 45.22		PSD7B_ARATH (15-307): 3.7e-57: 188: 18.09
+	At
		188943 PRS4A_ARATH (7-393): 5.26e-135: 395: 45.22		PSD7A_ARATH (15-307): 4.68e-57: 188: 17.76
+	Hs
		730324 PRS7_HUMAN (80-388): 2.37e-112: 337: 56.31		CSN5_HUMAN (28-304): 3.44e-73: 230: 30.10
+	Hs
		798615 PRS6B_HUMAN (10-396): 9.6e-118: 350: 42.12		PSMD7_HUMAN (27-307): 4.23e-59: 193: 19.80
+	Hs
		730219 PRS7_HUMAN (80-388): 2.37e-112: 337: 56.31		PSMD7_HUMAN (27-307): 4.23e-59: 193: 19.80
+	Sc
		968091 PRS8_YEAST (6-403): 7.89e-121: 358: 76.38		RPN8_YEAST (28-184): 4.36e-32: 123: 26.38
+	Sc
		703971 PRS7_YEAST (80-389): 1.94e-109: 331: 55.81		RPN8_YEAST (28-184): 4.36e-32: 123: 26.38
+	Dm
		1358678 Q9W414_DROME (4-94): 1.61e-11: 67.5: 13.19		PSDE_DROME (1-308): 7.51e-111: 325: 67.86
+	Dm
		640797 Q9W414_DROME (4-94): 1.61e-11: 67.5: 13.19		PSMD7_DROME (26-307): 6.44e-60: 196: 19.05