HitPredict

Interactor 1: ELK3 (P41970)
ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2)
Gene: ELK3

Interactor 2: SP4 (Q02446)
Transcription factor Sp4 (SPR-1)
Gene: SP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 407 Hs			1 784
+	Hs
		785353 ELK3_HUMAN (19-407): 1.88e-65: 216: 100.00		SP2_HUMAN (34-729): 1.28e-136: 419: 32.96
+	Hs
		968978 ELF4_HUMAN (3-398): 1.84e-35: 139: 22.87		SP2_HUMAN (34-729): 1.28e-136: 419: 32.96
+	Hs
		970908 GABPA_HUMAN (2-137): 6.47e-48: 171: 42.65		SP3_HUMAN (21-733): 5.86e-110: 355: 37.67
+	Hs
		987788 GABPA_HUMAN (2-137): 6.47e-48: 171: 42.65		SP7_HUMAN (625-782): 9.77e-42: 160: 54.66
+	Hs
		1077576 ELF2_HUMAN (4-376): 1.62e-41: 156: 21.87		SP7_HUMAN (625-782): 9.77e-42: 160: 54.66
+	Hs
		965411 FLI1_HUMAN (3-167): 1.53e-39: 148: 35.71		SP7_HUMAN (625-782): 9.77e-42: 160: 54.66
+	Hs
		987802 GABPA_HUMAN (2-137): 6.47e-48: 171: 42.65		KLF16_HUMAN (645-729): 4.98e-35: 135: 65.88
+	Dm
		2605 ETS3_DROME (3-175): 2.11e-35: 137: 33.53		A0A0B4KHC8_DROME (615-735): 7.87e-41: 163: 74.38
+	Dm
		669732 ETS3_DROME (3-175): 2.11e-35: 137: 33.53		Q9VCB2_DROME (615-735): 2.47e-40: 162: 74.38
+	Hs
		1077593 ELF2_HUMAN (4-376): 1.62e-41: 156: 21.87		KLF16_HUMAN (645-729): 4.98e-35: 135: 65.88
+	Hs
		840425 ERF_HUMAN (4-360): 1.21e-42: 158: 21.80		KLF15_HUMAN (645-730): 2.65e-29: 123: 62.79
+	Hs
		692179 ELF1_HUMAN (4-377): 1.93e-37: 145: 20.78		KLF16_HUMAN (645-729): 4.98e-35: 135: 65.88
+	Dm
		669721 ETS3_DROME (3-175): 2.11e-35: 137: 33.53		Q8IPV7_DROME (649-736): 6.6e-30: 123: 67.05
+	Hs
		965403 FLI1_HUMAN (3-167): 1.53e-39: 148: 35.71		KLF1_HUMAN (636-729): 7.13e-26: 112: 55.21
+	Dm
		669707 ETS3_DROME (3-175): 2.11e-35: 137: 33.53		Q4R0P9_DROME (649-736): 1.57e-28: 121: 67.05
+	Dm
		669701 ETS3_DROME (3-175): 2.11e-35: 137: 33.53		Q0IGQ2_DROME (638-732): 7.05e-28: 116: 48.42
+	Hs
		435065 GABPA_HUMAN (2-137): 6.47e-48: 171: 42.65		SP1_HUMAN (705-775): 1.33e-12: 73.5: 19.18
+	Hs
		434920 ETS1_HUMAN (3-111): 1.03e-45: 164: 45.87		SP1_HUMAN (705-775): 1.33e-12: 73.5: 19.18
+	Hs
		987765 GABPA_HUMAN (2-137): 6.47e-48: 171: 42.65		KLF9_HUMAN (671-733): 7.96e-10: 62: 43.08
+	Hs
		434971 ELF1_HUMAN (4-377): 1.93e-37: 145: 20.78		SP1_HUMAN (705-775): 1.33e-12: 73.5: 19.18