HitPredict

Interactor 1: ELK3 (P41970)
ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2)
Gene: ELK3

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007165 - signal transduction GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 407 Hs			1 770
+	Hs
		794534 ETV4_HUMAN (3-143): 9.93e-42: 155: 40.82		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980640 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		507403 ERG_HUMAN (3-164): 1.27e-31: 127: 37.58		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980949 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		TLE4_HUMAN (1-770): 0: 562: 86.27
+	Hs
		542002 ETS1_HUMAN (3-111): 1.03e-45: 164: 45.87		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		781618 ETV6_HUMAN (7-110): 6.74e-38: 144: 34.23		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		980853 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		507404 ERG_HUMAN (3-164): 1.27e-31: 127: 37.58		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Dm
		558359 ETS3_DROME (3-175): 2.11e-35: 137: 33.53		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Hs
		840370 ERF_HUMAN (4-360): 1.21e-42: 158: 21.80		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		993566 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Ce
		106121 G5EDL0_CAEEL (1-392): 1.97e-39: 148: 26.85		UNC37_CAEEL (18-684): 5.47e-79: 267: 19.06
+	Hs
		507408 ERG_HUMAN (3-164): 1.27e-31: 127: 37.58		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		840414 ERF_HUMAN (4-360): 1.21e-42: 158: 21.80		TBL1R_HUMAN (558-769): 4.54e-47: 177: 15.65
+	Hs
		245579 ERF_HUMAN (4-360): 1.21e-42: 158: 21.80		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		840410 ERF_HUMAN (4-360): 1.21e-42: 158: 21.80		TBL1Y_HUMAN (569-769): 9.88e-45: 170: 16.06
+	Hs
		781217 ETV3_HUMAN (4-395): 2.93e-39: 149: 23.15		TBL1Y_HUMAN (569-769): 9.88e-45: 170: 16.06
+	Hs
		781654 ETV6_HUMAN (7-110): 6.74e-38: 144: 34.23		TBL1Y_HUMAN (569-769): 9.88e-45: 170: 16.06
+	Hs
		692171 ELF1_HUMAN (4-377): 1.93e-37: 145: 20.78		SNR40_HUMAN (507-675): 1.08e-09: 62.8: 28.18
+	Hs
		781648 ETV6_HUMAN (7-110): 6.74e-38: 144: 34.23		SNR40_HUMAN (507-675): 1.08e-09: 62.8: 28.18