HitPredict

Interactor 1: ELK3 (P41970)
ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2)
Gene: ELK3

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 407 Hs			1 350
+	Hs
		692180 ELF1_HUMAN (4-377): 1.93e-37: 145: 20.78		PCGF6_HUMAN (1-350): 1.95e-96: 291: 100.00
+	Hs
		1304889 ELF4_HUMAN (3-398): 1.84e-35: 139: 22.87		PCGF6_HUMAN (1-350): 1.95e-96: 291: 100.00
+	Hs
		785400 ELK3_HUMAN (19-407): 1.88e-65: 216: 100.00		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		794565 ETV4_HUMAN (3-143): 9.93e-42: 155: 40.82		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		1108534 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Hs
		1304691 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		507498 ERG_HUMAN (3-164): 1.27e-31: 127: 37.58		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		1197583 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Hs
		542044 ETS1_HUMAN (3-111): 1.03e-45: 164: 45.87		COP1_HUMAN (126-321): 3.33e-26: 111: 16.00
+	Hs
		542752 ETS2_HUMAN (3-111): 9.5e-45: 162: 46.79		COP1_HUMAN (126-321): 3.33e-26: 111: 16.00
+	Mm
		1321861 ETV5_MOUSE (3-119): 4.33e-43: 159: 46.15		COP1_MOUSE (126-321): 3.53e-26: 111: 16.00
+	Hs
		781148 ETV5_HUMAN (3-119): 5.53e-42: 156: 47.01		COP1_HUMAN (126-321): 3.33e-26: 111: 16.00
+	Hs
		794556 ETV4_HUMAN (3-143): 9.93e-42: 155: 40.82		COP1_HUMAN (126-321): 3.33e-26: 111: 16.00
+	Hs
		507364 ERG_HUMAN (3-164): 1.27e-31: 127: 37.58		RO52_HUMAN (121-311): 4.15e-35: 135: 17.79
+	Hs
		1304061 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		840440 ETV1_HUMAN (3-124): 5.12e-37: 142: 45.90		COP1_HUMAN (126-321): 3.33e-26: 111: 16.00
+	Hs
		507493 ERG_HUMAN (3-164): 1.27e-31: 127: 37.58		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		988013 FEV_HUMAN (3-174): 3.76e-34: 129: 32.96		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Hs
		507407 ERG_HUMAN (3-164): 1.27e-31: 127: 37.58		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96