HitPredict

Interactor 1: MAD (P42003)
Protein mothers against dpp
Gene: MAD

Interactor 2: SUDX (Q9Y0H4)
E3 ubiquitin-protein ligase Su(dx) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Su(dx)) (Protein suppressor of deltex)
Gene: Su(dx)

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	15575970
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008586 - imaginal disc-derived wing vein morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 455 Dm			1 949
+	Hs
		1305881 SMAD5_HUMAN (14-455): 0: 587: 72.04		WWP1_HUMAN (27-949): 0: 858: 51.42
+	Hs
		1078757 SMAD1_HUMAN (17-455): 0: 584: 73.22		WWP1_HUMAN (27-949): 0: 858: 51.42
+	Hs
		950248 SMAD3_HUMAN (17-455): 0: 556: 59.96		ITCH_HUMAN (34-949): 0: 882: 49.02
+	Hs
		950278 SMAD3_HUMAN (17-455): 0: 556: 59.96		WWP1_HUMAN (27-949): 0: 858: 51.42
+	Hs
		125369 SMAD3_HUMAN (17-455): 0: 556: 59.96		WWP2_HUMAN (34-949): 0: 844: 52.01
+	Hs
		950249 SMAD3_HUMAN (17-455): 0: 556: 59.96		NED4L_HUMAN (45-946): 0: 812: 32.00
+	Hs
		808240 SMAD5_HUMAN (14-455): 0: 587: 72.04		NEDD4_HUMAN (120-946): 0: 712: 33.81
+	Hs
		808135 SMAD1_HUMAN (17-455): 0: 584: 73.22		NEDD4_HUMAN (120-946): 0: 712: 33.81
+	Hs
		808087 SMAD3_HUMAN (17-455): 0: 556: 59.96		NEDD4_HUMAN (120-946): 0: 712: 33.81
+	Dm
		785477 MAD_DROME (1-455): 0: 653: 100.00		SMUF1_DROME (42-560): 2.72e-42: 169: 14.26
+	Hs
		1305888 SMAD5_HUMAN (14-455): 0: 587: 72.04		SMUF1_HUMAN (37-459): 6.6e-42: 166: 15.31
+	Hs
		1078761 SMAD1_HUMAN (17-455): 0: 584: 73.22		SMUF1_HUMAN (37-459): 6.6e-42: 166: 15.31
+	Hs
		1305886 SMAD5_HUMAN (14-455): 0: 587: 72.04		SMUF2_HUMAN (42-433): 6.14e-34: 141: 18.34
+	Mm
		56826 SMAD1_MOUSE (17-455): 0: 586: 73.22		SMUF2_MOUSE (42-433): 6.95e-34: 141: 18.34
+	Hs
		1078760 SMAD1_HUMAN (17-455): 0: 584: 73.22		SMUF2_HUMAN (42-433): 6.14e-34: 141: 18.34
+	Hs
		950291 SMAD3_HUMAN (17-455): 0: 556: 59.96		SMUF1_HUMAN (37-459): 6.6e-42: 166: 15.31
+	Hs
		950287 SMAD3_HUMAN (17-455): 0: 556: 59.96		SMUF2_HUMAN (42-433): 6.14e-34: 141: 18.34
+	Hs
		1305892 SMAD5_HUMAN (14-455): 0: 587: 72.04		HECW2_HUMAN (151-621): 3.58e-15: 82.6: 13.83
+	Mm
		936618 SMAD1_MOUSE (17-455): 0: 586: 73.22		SMUF1_MOUSE (330-480): 6.23e-14: 78: 23.67
+	Xl
		945613 P79947_XENLA (17-455): 0: 587: 72.94		SMUF1_XENLA (294-446): 1.38e-11: 70.7: 21.56