HitPredict

Interactor 1: ACTY (P42025)
Beta-centractin (Actin-related protein 1B) (ARP1B)
Gene: ACTR1B

Interactor 2: CAZA1 (P52907)
F-actin-capping protein subunit alpha-1 (CapZ alpha-1)
Gene: CAPZA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~F-actin_cap_A
Common GO terms	GO:0005576 - extracellular region GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 286
+	Hs
		785519 ACTY_HUMAN (1-376): 0: 776: 100.00		CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71
+	Hs
		857093 ACTZ_HUMAN (1-376): 0: 728: 90.43		CAZA1_HUMAN (1-286): 1.77e-164: 459: 100.00
+	Hs
		812979 ACTZ_HUMAN (1-376): 0: 728: 90.43		CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71
+	Hs
		857090 ACTB_HUMAN (8-376): 0: 581: 53.62		CAZA1_HUMAN (1-286): 1.77e-164: 459: 100.00
+	Hs
		857100 ACTG_HUMAN (7-376): 0: 581: 53.74		CAZA1_HUMAN (1-286): 1.77e-164: 459: 100.00
+	Hs
		857101 ACTC_HUMAN (5-376): 0: 577: 53.72		CAZA1_HUMAN (1-286): 1.77e-164: 459: 100.00
+	Hs
		812976 ACTB_HUMAN (8-376): 0: 581: 53.62		CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71
+	Hs
		812985 ACTG_HUMAN (7-376): 0: 581: 53.74		CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71
+	Hs
		812987 ACTC_HUMAN (5-376): 0: 577: 53.72		CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71
+	Hs
		812988 ACTS_HUMAN (5-376): 0: 576: 53.19		CAZA2_HUMAN (1-286): 6.84e-159: 445: 86.71
+	Dm
		862585 ACT3_DROME (8-376): 0: 575: 53.89		CAPZA_DROME (8-284): 3.9e-141: 400: 64.52