HitPredict

Interactor 1: ACTY (P42025)
Beta-centractin (Actin-related protein 1B) (ARP1B)
Gene: ACTR1B

Interactor 2: DCTN2 (Q13561)
Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin)
Gene: DCTN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	27173435, 26186194, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Dynamitin
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005869 - dynactin complex GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 401
+	Hs
		897050 ACTZ_HUMAN (1-376): 0: 728: 90.43		DCTN2_HUMAN (1-401): 0: 525: 100.00
+	Hs
		891746 ACTB_HUMAN (8-376): 0: 581: 53.62		DCTN2_HUMAN (1-401): 0: 525: 100.00
+	Hs
		929854 ACTG_HUMAN (7-376): 0: 581: 53.74		DCTN2_HUMAN (1-401): 0: 525: 100.00
+	Hs
		932142 ACTC_HUMAN (5-376): 0: 577: 53.72		DCTN2_HUMAN (1-401): 0: 525: 100.00
+	Dm
		800135 ACTZ_DROME (1-376): 0: 641: 77.13		DCTN2_DROME (1-399): 2.13e-141: 409: 32.26
+	Ce
		998315 Q9NA98_CAEEL (4-376): 0: 545: 67.56		DCTN2_CAEEL (18-399): 3.99e-112: 333: 22.54