HitPredict

Interactor 1: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	11278462, 20576130
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042127 - regulation of cell population proliferation GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 750 Hs			1 1052
+	Hs
		776657 STAT3_HUMAN (1-740): 0: 864: 52.61		FAK1_HUMAN (1-1052): 0: 1127: 100.00
+	Hs
		776680 STAT3_HUMAN (1-740): 0: 864: 52.61		FAK2_HUMAN (35-1043): 0: 852: 44.78
+	Hs
		786328 STAT1_HUMAN (1-750): 0: 988: 100.00		ACK1_HUMAN (386-1032): 6.61e-120: 395: 22.90
+	Hs
		373833 STAT1_HUMAN (1-750): 0: 988: 100.00		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	Hs
		522836 STAT1_HUMAN (1-750): 0: 988: 100.00		SRC_HUMAN (415-689): 1.19e-113: 363: 38.77
+	Mm
		786520 STAT3_MOUSE (1-740): 0: 865: 52.61		FER_MOUSE (86-681): 7.01e-147: 460: 25.33
+	Hs
		426949 STAT3_HUMAN (1-740): 0: 864: 52.61		FES_HUMAN (85-681): 2.15e-126: 406: 22.89
+	Hs
		776626 STAT3_HUMAN (1-740): 0: 864: 52.61		EPHA5_HUMAN (208-760): 5.09e-123: 403: 26.17
+	Hs
		201250 STAT3_HUMAN (1-740): 0: 864: 52.61		M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16
+	Hs
		373819 STAT3_HUMAN (1-740): 0: 864: 52.61		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	Hs
		412065 STAT3_HUMAN (1-740): 0: 864: 52.61		FYN_HUMAN (265-689): 7.19e-119: 377: 26.68
+	Hs
		601474 STAT3_HUMAN (1-740): 0: 864: 52.61		FGFR2_HUMAN (343-723): 4.94e-115: 376: 28.33
+	Hs
		507894 STAT3_HUMAN (1-740): 0: 864: 52.61		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		522829 STAT3_HUMAN (1-740): 0: 864: 52.61		SRC_HUMAN (415-689): 1.19e-113: 363: 38.77
+	Mm
		403422 STAT3_MOUSE (1-740): 0: 865: 52.61		SRC_MOUSE (415-689): 7.2e-113: 361: 38.41
+	Hs
		411624 STAT3_HUMAN (1-740): 0: 864: 52.61		LCK_HUMAN (412-691): 7.42e-111: 355: 37.37
+	Hs
		849879 STA5B_HUMAN (1-749): 0: 787: 28.82		EPHA4_HUMAN (372-763): 1.33e-119: 393: 31.90
+	Hs
		601481 STA5B_HUMAN (1-749): 0: 787: 28.82		FGFR2_HUMAN (343-723): 4.94e-115: 376: 28.33
+	Hs
		601477 STA5A_HUMAN (1-748): 0: 780: 28.14		FGFR2_HUMAN (343-723): 4.94e-115: 376: 28.33
+	Hs
		849893 STA5B_HUMAN (1-749): 0: 787: 28.82		ERBB4_HUMAN (408-695): 1.19e-58: 222: 39.53