HitPredict

Interactor 1: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	27229929, 12270932, 18832710
Identification Methods	two hybrid, enzymatic study, pull down, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex and 1 others more... GO:0045296 - cadherin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 750 Hs			1 593
+	Mm
		665977 STAT1_MOUSE (1-750): 0: 969: 92.27		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		776659 STAT3_HUMAN (1-740): 0: 864: 52.61		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665813 STAT3_HUMAN (1-740): 0: 864: 52.61		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		665978 STAT3_MOUSE (1-740): 0: 865: 52.61		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Mm
		719288 STA5A_MOUSE (1-748): 0: 793: 27.79		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		849884 STA5B_HUMAN (1-749): 0: 787: 28.82		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		786601 STA5A_HUMAN (1-748): 0: 780: 28.14		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665833 STA5B_HUMAN (1-749): 0: 787: 28.82		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		573602 STAT3_HUMAN (1-740): 0: 864: 52.61		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		570492 STAT1_HUMAN (1-750): 0: 988: 100.00		PTN2_HUMAN (263-518): 6.71e-51: 182: 39.00
+	Hs
		573623 STA5B_HUMAN (1-749): 0: 787: 28.82		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		573605 STA5A_HUMAN (1-748): 0: 780: 28.14		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Hs
		146922 STAT3_HUMAN (1-740): 0: 864: 52.61		PTPRT_HUMAN (35-524): 6.59e-70: 247: 18.90
+	Hs
		570489 STAT3_HUMAN (1-740): 0: 864: 52.61		PTN2_HUMAN (263-518): 6.71e-51: 182: 39.00
+	Mm
		786649 STA5A_MOUSE (1-748): 0: 793: 27.79		PTN2_MOUSE (263-518): 2.21e-50: 181: 39.00
+	Mm
		786664 STA5B_MOUSE (1-748): 0: 782: 28.13		PTN2_MOUSE (263-518): 2.21e-50: 181: 39.00
+	Hs
		570493 STAT6_HUMAN (1-740): 0: 638: 26.43		PTN2_HUMAN (263-518): 6.71e-51: 182: 39.00