HitPredict

Interactor 1: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	22057045
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 750 Hs			1 913
+	Hs
		776663 STAT3_HUMAN (1-740): 0: 864: 52.61		DDR1_HUMAN (1-913): 0: 911: 100.00
+	Hs
		849885 STA5B_HUMAN (1-749): 0: 787: 28.82		DDR1_HUMAN (1-913): 0: 911: 100.00
+	Hs
		522836 STAT1_HUMAN (1-750): 0: 988: 100.00		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Mm
		403422 STAT3_MOUSE (1-740): 0: 865: 52.61		SRC_MOUSE (361-912): 1.24e-128: 399: 23.65
+	Hs
		522829 STAT3_HUMAN (1-740): 0: 864: 52.61		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		384428 STAT1_HUMAN (1-750): 0: 988: 100.00		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		609197 STAT3_HUMAN (1-740): 0: 864: 52.61		FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16
+	Hs
		601474 STAT3_HUMAN (1-740): 0: 864: 52.61		FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05
+	Hs
		507894 STAT3_HUMAN (1-740): 0: 864: 52.61		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Rn
		94369 F1M9D6_RAT (1-750): 0: 982: 92.73		INSR_RAT (600-908): 1.98e-51: 198: 36.25
+	Hs
		601481 STA5B_HUMAN (1-749): 0: 787: 28.82		FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05
+	Hs
		601477 STA5A_HUMAN (1-748): 0: 780: 28.14		FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05
+	Hs
		384414 STAT3_HUMAN (1-740): 0: 864: 52.61		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		776653 STAT3_HUMAN (1-740): 0: 864: 52.61		ROR1_HUMAN (604-902): 1.59e-55: 209: 37.79
+	Hs
		411328 STAT3_HUMAN (1-740): 0: 864: 52.61		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		435568 STAT3_HUMAN (1-740): 0: 864: 52.61		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Hs
		384522 STA5B_HUMAN (1-749): 0: 787: 28.82		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		411341 STA5B_HUMAN (1-749): 0: 787: 28.82		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		411330 STA5A_HUMAN (1-748): 0: 780: 28.14		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42