HitPredict

Interactor 1: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.786

Property	Details
Experiments	20936779, 26966684
Identification Methods	two hybrid, pull down, two hybrid pooling approach
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0045296 - cadherin binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 750 Hs			1 2472
+	Hs
		786312 STAT1_HUMAN (1-750): 0: 988: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		786352 STAT1_HUMAN (1-750): 0: 988: 100.00		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		506810 STAT1_HUMAN (1-750): 0: 988: 100.00		SPTB1_HUMAN (1743-2409): 3.32e-13: 78.1: 19.70
+	Hs
		211521 STAT1_HUMAN (1-750): 0: 988: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Mm
		786538 STAT3_MOUSE (1-740): 0: 865: 52.61		SPTB2_MOUSE (1408-2420): 1.22e-29: 132: 18.86
+	Hs
		786483 STAT6_HUMAN (1-740): 0: 638: 26.43		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18