HitPredict

Interactor 1: STAT3 (P42227)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Interactor 2: JAK3 (Q62137)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3)
Gene: JAK3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 22402124, 14976041
Identification Methods affinity chromatography technology, electrophoretic mobility supershift assay, enzymatic study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FERM_F1~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006366 - transcription by RNA polymerase II
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
GO:0016310 - phosphorylation
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 770
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024