HitPredict

Interactor 1: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	9837784, 9657743, 9872990
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, far western blotting
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1, SH2~SH3_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0038026 - reelin-mediated signaling pathway
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 794 Hs			1 303
+	Hs
		802809 STA5B_HUMAN (1-774): 0: 997: 93.84		CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00
+	Hs
		802601 STAT4_HUMAN (1-738): 0: 715: 29.34		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		776779 STAT3_HUMAN (1-723): 0: 736: 29.94		SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69
+	Hs
		776638 STAT3_HUMAN (1-723): 0: 736: 29.94		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32