HitPredict

Interactor 1: GRIA2 (P42262)
Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2)
Gene: GRIA2

Interactor 2: GRIP1 (Q9Y3R0)
Glutamate receptor-interacting protein 1 (GRIP-1)
Gene: GRIP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	21847098, 11891216, 18311135
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0030425 - dendrite
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 883 Hs			1 1128
+	Mm
		621022 GRIA2_MOUSE (1-883): 0: 921: 99.66		GRIP1_MOUSE (1-1128): 0: 657: 95.83
+	Rn
		585169 GRIA2_RAT (1-883): 0: 919: 99.55		GRIP1_RAT (1-1128): 0: 640: 93.88
+	Hs
		786768 GRIA3_HUMAN (2-883): 0: 880: 71.46		GRIP1_HUMAN (1-1128): 0: 676: 100.00
+	Hs
		786717 GRIA1_HUMAN (4-862): 0: 862: 70.55		GRIP1_HUMAN (1-1128): 0: 676: 100.00
+	Rn
		585193 GRIA3_RAT (2-883): 0: 877: 71.57		GRIP1_RAT (1-1128): 0: 640: 93.88
+	Rn
		585145 GRIA1_RAT (4-862): 0: 858: 70.21		GRIP1_RAT (1-1128): 0: 640: 93.88
+	Rn
		585210 GRIA4_RAT (1-860): 0: 855: 73.33		GRIP1_RAT (1-1128): 0: 640: 93.88
+	Rn
		585187 GRIA2_RAT (1-883): 0: 919: 99.55		GRIP2_RAT (1-1105): 6.49e-159: 501: 56.63
+	Rn
		585198 GRIA3_RAT (2-883): 0: 877: 71.57		GRIP2_RAT (1-1105): 6.49e-159: 501: 56.63
+	Hs
		786726 GRIA2_HUMAN (1-883): 0: 923: 100.00		DLG4_HUMAN (999-1126): 8.04e-15: 81.3: 20.74
+	Mm
		620965 GRIA2_MOUSE (1-883): 0: 921: 99.66		DLG4_MOUSE (999-1126): 8.76e-15: 81.3: 20.74
+	Mm
		621019 GRIA2_MOUSE (1-883): 0: 921: 99.66		LNX2_MOUSE (916-1116): 1.03e-10: 67.8: 13.59
+	Hs
		786757 GRIA3_HUMAN (2-883): 0: 880: 71.46		DLG4_HUMAN (999-1126): 8.04e-15: 81.3: 20.74
+	Mm
		1143566 GRIA3_MOUSE (2-883): 0: 877: 70.67		DLG4_MOUSE (999-1126): 8.76e-15: 81.3: 20.74
+	Hs
		786696 GRIA1_HUMAN (4-862): 0: 862: 70.55		DLG1_HUMAN (9-377): 2.52e-17: 89.7: 13.17
+	Rn
		585151 GRIA1_RAT (4-862): 0: 858: 70.21		DLG1_RAT (9-377): 2.47e-15: 83.2: 13.98
+	Rn
		585138 GRIA1_RAT (4-862): 0: 858: 70.21		DLG4_RAT (999-1126): 7.26e-15: 81.7: 20.74
+	Mm
		620904 GRIA1_MOUSE (4-862): 0: 855: 69.28		DLG2_MOUSE (998-1124): 1.41e-15: 84: 18.57
+	Mm
		620881 GRIA1_MOUSE (4-862): 0: 855: 69.28		DLG3_MOUSE (792-1120): 2.61e-15: 83.2: 13.99
+	Mm
		620892 GRIA1_MOUSE (4-862): 0: 855: 69.28		DLG4_MOUSE (999-1126): 8.76e-15: 81.3: 20.74