HitPredict

Interactor 1: MTREX (P42285)
Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)
Gene: MTREX

Interactor 2: NCBP2 (P52298)
Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)
Gene: NCBP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26496610, 32960270
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1042 Hs			1 156
+	Sc
		810941 MTR4_YEAST (61-1042): 0: 723: 52.39		NCBP2_YEAST (10-150): 3.97e-39: 132: 52.48
+	Sp
		143177 YE02_SCHPO (22-1042): 0: 669: 46.04		NCBP2_SCHPO (17-154): 1.84e-37: 128: 57.97
+	Sp
		143184 YE02_SCHPO (22-1042): 0: 669: 46.04		YKCG_SCHPO (36-123): 2.21e-30: 115: 30.68
+	Hs
		571369 DDX5_HUMAN (18-569): 2.43e-96: 319: 12.00		NCBP2_HUMAN (1-156): 2.27e-48: 154: 100.00
+	Hs
		516589 ASCC3_HUMAN (14-634): 8.79e-97: 339: 17.59		PABP1_HUMAN (4-156): 7.45e-28: 109: 18.41
+	Sc
		624191 DBP2_YEAST (1-565): 8.16e-93: 308: 11.53		NCBP2_YEAST (10-150): 3.97e-39: 132: 52.48
+	Hs
		958241 DHX36_HUMAN (6-926): 2.72e-106: 357: 12.46		RBM3_HUMAN (42-116): 2.8e-18: 78.1: 36.00
+	Hs
		272072 U520_HUMAN (87-826): 1.97e-76: 278: 15.66		NCBP2_HUMAN (1-156): 2.27e-48: 154: 100.00
+	Hs
		571469 DDX5_HUMAN (18-569): 2.43e-96: 319: 12.00		ELAV1_HUMAN (7-123): 1.27e-24: 98.4: 18.49
+	Sc
		697273 BRR2_YEAST (92-843): 2.28e-78: 284: 15.78		NCBP2_YEAST (10-150): 3.97e-39: 132: 52.48
+	Hs
		1077436 DDX17_HUMAN (66-594): 5.59e-93: 314: 11.35		ELAV1_HUMAN (7-123): 1.27e-24: 98.4: 18.49
+	Mm
		857351 Q8BTS0_MOUSE (18-569): 3.03e-96: 319: 11.83		TIA1_MOUSE (1-140): 7e-21: 89.1: 19.58
+	Mm
		936480 DDX5_MOUSE (18-569): 6.45e-97: 321: 11.83		TIAR_MOUSE (1-155): 2.19e-19: 84.9: 16.46
+	Mm
		857323 DDX17_MOUSE (66-594): 1.06e-93: 314: 11.35		TIA1_MOUSE (1-140): 7e-21: 89.1: 19.58
+	Sc
		697283 BRR2_YEAST (92-843): 2.28e-78: 284: 15.78		HSH49_YEAST (37-113): 2.85e-25: 97.8: 37.18
+	Hs
		1073611 DDX17_HUMAN (66-594): 5.59e-93: 314: 11.35		SF3B4_HUMAN (30-116): 8.18e-11: 60.8: 23.86
+	Hs
		958199 DDX6L_HUMAN (122-296): 2.17e-11: 70.5: 30.00		RBM3_HUMAN (42-116): 2.8e-18: 78.1: 36.00