HitPredict

Interactor 1: PK3CA (P42336)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29729098
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm GO:0050852 - T cell receptor signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1068 Hs			1 522
+	Hs
		135762 P3C2B_HUMAN (283-1064): 0: 748: 31.67		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		128783 P3C2A_HUMAN (300-1064): 0: 727: 31.92		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		128802 P3C2A_HUMAN (300-1064): 0: 727: 31.92		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		944236 PRKDC_HUMAN (477-1017): 1.25e-91: 325: 17.90		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		301756 PRKDC_HUMAN (477-1017): 1.25e-91: 325: 17.90		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		944338 PRKDC_HUMAN (477-1017): 1.25e-91: 325: 17.90		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84