HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: RICTR (Q6R327)
Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)
Gene: RICTOR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.99	1.00	0.997

The method score is based on:

Property	Details
Experiments	18030348, 18339839, 18570873, 21343617, 23872070, 22084251, 15467718, 15268862, 25273559, 21795849, 31665642, 16919458, 16962653, 17043309, 33378666, 22307628, 24036451, 33416177, 29567957, 19299511 and 47 others more... 35271311, 35982899, 35973513, 37120454, 17461779, 21045808, 22285861, 16603397, 17386266, 19145465, 18566587, 21177249, 19875983, 22990118, 19446321, 17565979, 18505677, 18566586, 19114562, 20978191, 17277771, 25897075, 29059166, 30865892, 18504440, 16183647, 34171383, 34331380, 26588989, 20427287, 22544753, 23297343, 19619545, 21321085, 27043084, 23263282, 18614546, 15718470, 15809305, 17599906, 18925875, 17545609, 17604271, 18411301, 23953116, 21376236, 24375676
Identification Methods	affinity chromatography technology, pull down, two hybrid, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, in-gel kinase assay, tandem affinity purification
Interaction Type	physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	FRB_dom~RICTOR_N
Common GO terms	GO:0005829 - cytosol GO:0007010 - cytoskeleton organization GO:0018105 - peptidyl-serine phosphorylation GO:0030307 - positive regulation of cell growth GO:0030838 - positive regulation of actin filament polymerization and 7 others more... GO:0031669 - cellular response to nutrient levels GO:0031932 - TORC2 complex GO:0032956 - regulation of actin cytoskeleton organization GO:0043022 - ribosome binding GO:0043066 - negative regulation of apoptotic process GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	2549
Hs

1	1708

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024