HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: P2RY8 (Q86VZ1)
P2Y purinoceptor 8 (P2Y8)
Gene: P2RY8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2549 Hs			1 359
+	Hs
		787471 MTOR_HUMAN (1-2549): 0: 2102: 100.00		GPR17_HUMAN (15-331): 1.86e-84: 262: 28.53
+	Hs
		787434 MTOR_HUMAN (1-2549): 0: 2102: 100.00		CXCR4_HUMAN (23-308): 3.55e-84: 261: 25.26
+	Hs
		723279 MTOR_HUMAN (1-2549): 0: 2102: 100.00		APJ_HUMAN (14-346): 1.38e-68: 221: 22.97
+	Hs
		787417 MTOR_HUMAN (1-2549): 0: 2102: 100.00		NPY2R_HUMAN (9-348): 4.28e-66: 215: 18.34
+	Hs
		787488 MTOR_HUMAN (1-2549): 0: 2102: 100.00		P2RY6_HUMAN (26-308): 1.22e-29: 117: 31.33
+	Hs
		787552 MTOR_HUMAN (1-2549): 0: 2102: 100.00		CML1_HUMAN (24-330): 1.18e-25: 107: 27.41
+	Hs
		1030922 ATM_HUMAN (387-2548): 0: 894: 14.98		GPR17_HUMAN (15-331): 1.86e-84: 262: 28.53
+	Hs
		895616 ATM_HUMAN (387-2548): 0: 894: 14.98		CXCR4_HUMAN (23-308): 3.55e-84: 261: 25.26
+	Hs
		1031558 ATM_HUMAN (387-2548): 0: 894: 14.98		P2RY8_HUMAN (1-359): 1.75e-78: 246: 100.00
+	Hs
		723296 ATM_HUMAN (387-2548): 0: 894: 14.98		APJ_HUMAN (14-346): 1.38e-68: 221: 22.97
+	Hs
		723037 ATM_HUMAN (387-2548): 0: 894: 14.98		OPRM_HUMAN (12-356): 5.97e-67: 218: 22.51
+	Hs
		824699 ATM_HUMAN (387-2548): 0: 894: 14.98		NPY2R_HUMAN (9-348): 4.28e-66: 215: 18.34
+	Hs
		1030924 ATR_HUMAN (186-2548): 0: 816: 14.82		GPR17_HUMAN (15-331): 1.86e-84: 262: 28.53
+	Hs
		1031594 ATM_HUMAN (387-2548): 0: 894: 14.98		LPAR4_HUMAN (29-301): 9.42e-49: 169: 36.14
+	Hs
		798422 ATM_HUMAN (387-2548): 0: 894: 14.98		LPAR6_HUMAN (29-301): 3.51e-39: 144: 32.28
+	Hs
		723038 ATR_HUMAN (186-2548): 0: 816: 14.82		OPRM_HUMAN (12-356): 5.97e-67: 218: 22.51
+	Hs
		126587 ATM_HUMAN (387-2548): 0: 894: 14.98		P2Y10_HUMAN (30-307): 9.64e-30: 118: 34.46
+	Hs
		429015 PRKDC_HUMAN (695-2548): 0: 686: 14.83		ADRB2_HUMAN (4-332): 2.82e-71: 229: 15.88
+	Hs
		666304 PRKDC_HUMAN (695-2548): 0: 686: 14.83		NK3R_HUMAN (4-337): 4.85e-64: 212: 18.61
+	Hs
		126582 PRKDC_HUMAN (695-2548): 0: 686: 14.83		P2Y10_HUMAN (30-307): 9.64e-30: 118: 34.46