HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: RPTOR (Q8N122)
Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
Gene: RPTOR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 18030348, 18519641, 18570873, 12408816, 24516643, 25940091, 26522726, 15467718, 15268862, 25273559, 26348909, 30865892, 21795849, 12747827, 12150926, 16837165, 16798736, 16919458, 16631613, 16962653 and 66 others

more...
Identification Methods affinity chromatography technology, biochemical, enzymatic study, two hybrid, anti bait coimmunoprecipitation, solid phase assay, anti tag coimmunoprecipitation
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PI3_PI4_kinase~WD40
Common GO terms GO:0001558 - regulation of cell growth
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
and 19 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 2549
Hs

1 1335
+ Mm
+ Mm
+ Dm
+ At
+ Hs
+ Mm
+ Hs
+ Hs
+ Sp
+ Sc
+ Sp
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024