HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: DPTOR (Q8TB45)
DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)
Gene: DEPTOR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	22017877, 22017875, 19446321, 33995662, 35216969
Identification Methods	enzymatic study, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DEP~FAT
Common GO terms	GO:0005765 - lysosomal membrane GO:0045792 - negative regulation of cell size
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 409
+	Hs
		787532 MTOR_HUMAN (1-2549): 0: 2102: 100.00		PREX1_HUMAN (23-382): 2.96e-138: 434: 29.29
+	Hs
		787514 MTOR_HUMAN (1-2549): 0: 2102: 100.00		PREX2_HUMAN (27-388): 3.59e-133: 419: 29.18