HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: RUVB2 (Q9Y230)
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)
Gene: RUVBL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22544753
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2549 Hs			1 463
+	Hs
		787606 MTOR_HUMAN (1-2549): 0: 2102: 100.00		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Dm
		1358868 TOR_DROME (17-2549): 0: 1785: 53.01		RUVB2_DROME (6-458): 0: 681: 78.15
+	Dm
		1366582 TOR_DROME (17-2549): 0: 1785: 53.01		RUVB1_DROME (8-452): 0: 619: 44.32
+	Hs
		1031646 ATM_HUMAN (387-2548): 0: 894: 14.98		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		1038195 ATR_HUMAN (186-2548): 0: 816: 14.82		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		1376985 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Sp
		294006 TRA1_SCHPO (15-2548): 0: 761: 12.87		RUVB2_SCHPO (7-451): 0: 660: 70.79
+	Hs
		944485 PRKDC_HUMAN (695-2548): 0: 686: 14.83		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Mm
		888083 TRRAP_MOUSE (60-2548): 0: 736: 13.31		RUVB1_MOUSE (8-451): 0: 656: 42.67
+	Sp
		1319465 TRA1_SCHPO (15-2548): 0: 761: 12.87		RUVB1_SCHPO (9-447): 0: 625: 44.03
+	Hs
		1377044 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Hs
		944486 PRKDC_HUMAN (695-2548): 0: 686: 14.83		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Sc
		755452 TRA1_YEAST (202-2549): 0: 657: 12.49		RUVB1_YEAST (12-451): 0: 605: 41.72
+	Dm
		1211950 TRA1_DROME (89-2548): 0: 641: 12.84		RUVB1_DROME (8-452): 0: 619: 44.32
+	Hs
		1300093 SMG1_HUMAN (1557-2531): 1.86e-123: 441: 18.35		RUVB2_HUMAN (1-463): 0: 718: 100.00
+	Hs
		1300094 SMG1_HUMAN (1557-2531): 1.86e-123: 441: 18.35		RUVB1_HUMAN (8-451): 0: 655: 42.67
+	Sc
		707958 GCN1_YEAST (666-1247): 2.46e-13: 78.5: 14.26		RUVB2_YEAST (7-451): 0: 650: 68.76
+	Sc
		715255 TOR1_YEAST (19-695): 1.8e-12: 75.9: 14.08		RUVB2_YEAST (7-451): 0: 650: 68.76
+	Sc
		707923 GCN1_YEAST (666-1247): 2.46e-13: 78.5: 14.26		RUVB1_YEAST (12-451): 0: 605: 41.72
+	Sc
		744167 ATR_YEAST (2477-2549): 3.41e-11: 71.7: 31.51		RUVB1_YEAST (12-451): 0: 605: 41.72