HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22544753, 20371770
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2549 Hs			1 456
+	Hs
		787605 MTOR_HUMAN (1-2549): 0: 2102: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Dm
		1366582 TOR_DROME (17-2549): 0: 1785: 53.01		RUVB1_DROME (1-455): 0: 660: 79.56
+	Dm
		1358868 TOR_DROME (17-2549): 0: 1785: 53.01		RUVB2_DROME (5-455): 0: 640: 45.25
+	Hs
		1031646 ATM_HUMAN (387-2548): 0: 894: 14.98		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1038195 ATR_HUMAN (186-2548): 0: 816: 14.82		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Mm
		888083 TRRAP_MOUSE (60-2548): 0: 736: 13.31		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Sp
		1319465 TRA1_SCHPO (15-2548): 0: 761: 12.87		RUVB1_SCHPO (1-456): 0: 671: 69.96
+	Hs
		1377044 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Sp
		294006 TRA1_SCHPO (15-2548): 0: 761: 12.87		RUVB2_SCHPO (1-455): 0: 639: 42.45
+	Hs
		944486 PRKDC_HUMAN (695-2548): 0: 686: 14.83		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1376985 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		944485 PRKDC_HUMAN (695-2548): 0: 686: 14.83		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		755452 TRA1_YEAST (202-2549): 0: 657: 12.49		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Dm
		1211950 TRA1_DROME (89-2548): 0: 641: 12.84		RUVB1_DROME (1-455): 0: 660: 79.56
+	Hs
		1300094 SMG1_HUMAN (1557-2531): 1.86e-123: 441: 18.35		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1300093 SMG1_HUMAN (1557-2531): 1.86e-123: 441: 18.35		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		707923 GCN1_YEAST (666-1247): 2.46e-13: 78.5: 14.26		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		744167 ATR_YEAST (2477-2549): 3.41e-11: 71.7: 31.51		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		707958 GCN1_YEAST (666-1247): 2.46e-13: 78.5: 14.26		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Sc
		715255 TOR1_YEAST (19-695): 1.8e-12: 75.9: 14.08		RUVB2_YEAST (5-455): 0: 627: 41.72