HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	23911927
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 522
+	Mm
		936284 MTOR_MOUSE (1-2549): 0: 2095: 98.94		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		787467 MTOR_HUMAN (1-2549): 0: 2102: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		301664 MTOR_HUMAN (1-2549): 0: 2102: 100.00		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		1031649 ATM_HUMAN (387-2548): 0: 894: 14.98		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		301799 ATM_HUMAN (387-2548): 0: 894: 14.98		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		1313389 TRRAP_HUMAN (925-2548): 0: 720: 15.53		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		585100 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		537146 TRRAP_HUMAN (925-2548): 0: 720: 15.53		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1297114 TRRAP_HUMAN (925-2548): 0: 720: 15.53		TRI47_HUMAN (67-316): 1.02e-36: 145: 17.84
+	Hs
		944236 PRKDC_HUMAN (695-2548): 0: 686: 14.83		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		301756 PRKDC_HUMAN (695-2548): 0: 686: 14.83		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		944338 PRKDC_HUMAN (695-2548): 0: 686: 14.83		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Hs
		1268288 GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00