HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: TELO2 (Q9Y4R8)
Telomere length regulation protein TEL2 homolog (Protein clk-2 homolog) (hCLK2)
Gene: TELO2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.684

Property	Details
Experiments	20801936, 18160036, 34171383
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 837
+	Mm
		1322171 MTOR_MOUSE (1-2549): 0: 2095: 98.94		TELO2_MOUSE (1-837): 0: 1067: 75.06
+	Dm
		1213249 TOR_DROME (17-2549): 0: 1785: 53.01		Q8IN05_DROME (121-829): 0: 646: 22.69
+	Sp
		1350677 TOR2_SCHPO (26-2549): 0: 1604: 42.48		TEL2_SCHPO (332-837): 3.18e-147: 456: 18.82
+	Mm
		1143875 ATM_MOUSE (44-2548): 0: 913: 14.68		TELO2_MOUSE (1-837): 0: 1067: 75.06
+	Hs
		1031650 ATM_HUMAN (387-2548): 0: 894: 14.98		TELO2_HUMAN (1-837): 0: 1020: 100.00
+	Hs
		1038199 ATR_HUMAN (186-2548): 0: 816: 14.82		TELO2_HUMAN (1-837): 0: 1020: 100.00
+	Sp
		145545 TOR1_SCHPO (113-2549): 0: 1330: 38.03		TEL2_SCHPO (332-837): 3.18e-147: 456: 18.82
+	Hs
		1377806 TRRAP_HUMAN (925-2548): 0: 720: 15.53		TELO2_HUMAN (1-837): 0: 1020: 100.00
+	Hs
		944493 PRKDC_HUMAN (695-2548): 0: 686: 14.83		TELO2_HUMAN (1-837): 0: 1020: 100.00
+	Hs
		1300095 SMG1_HUMAN (1557-2531): 1.86e-123: 441: 18.35		TELO2_HUMAN (1-837): 0: 1020: 100.00
+	Sp
		1336848 TRA1_SCHPO (15-2548): 0: 761: 12.87		TEL2_SCHPO (332-837): 3.18e-147: 456: 18.82
+	Sp
		1013452 YAMB_SCHPO (535-2548): 0: 712: 14.15		TEL2_SCHPO (332-837): 3.18e-147: 456: 18.82
+	Sp
		968997 RAD3_SCHPO (593-2549): 0: 661: 14.57		TEL2_SCHPO (332-837): 3.18e-147: 456: 18.82
+	Sp
		251731 ATM_SCHPO (1208-2548): 1.17e-170: 590: 18.23		TEL2_SCHPO (332-837): 3.18e-147: 456: 18.82
+	Sc
		744121 ATM_YEAST (1223-2549): 6.86e-154: 538: 15.87		TEL2_YEAST (510-738): 1.01e-63: 228: 20.25
+	Sc
		744152 ATR_YEAST (2477-2549): 3.41e-11: 71.7: 31.51		TEL2_YEAST (510-738): 1.01e-63: 228: 20.25