HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	31980649, 33961781, 19380743, 7797522, unassigned2173
Identification Methods	affinity chromatography technology, far western blotting, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0017124 - SH3 domain binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 304
+	Hs
		787862 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		787889 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		61732 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		A6H8W8_HUMAN (189-304): 6.66e-12: 68.3: 11.86
+	Hs
		787985 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86
+	Hs
		557629 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		787920 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Cl
		47357 A0A8I3PJA6_CANLF (1-896): 5.87e-149: 464: 92.91		F1PHV6_CANLF (157-302): 1.9e-10: 63.7: 11.04
+	Mm
		788010 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		ITSN1_MOUSE (143-302): 6.55e-13: 71.4: 10.98
+	Hs
		1349275 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86
+	Hs
		1078919 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		1285205 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		1078828 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		1078886 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		259644 LIPA2_HUMAN (210-884): 2.13e-31: 134: 11.53		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		924919 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Ce
		1353618 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		Q9U2T9_CAEEL (182-300): 9.9e-11: 64.7: 13.22
+	Ce
		1308360 Q9BIF4_CAEEL (7-213): 5.25e-19: 94.5: 37.55		Q9U2T9_CAEEL (182-300): 9.9e-11: 64.7: 13.22
+	Rn
		92844 E9PSY8_RAT (9-333): 4.64e-17: 88.3: 11.66		ITSN1_RAT (185-302): 1.12e-11: 67.5: 14.17
+	Hs
		61738 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		A6H8W8_HUMAN (189-304): 6.66e-12: 68.3: 11.86