HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11483962
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0006897 - endocytosis and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 870
+	Hs
		840840 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760488 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		840702 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760469 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Hs
		983379 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Rn
		599413 ITSN1_RAT (11-737): 4.81e-34: 143: 12.14		DYN1_RAT (1-846): 0: 994: 78.57
+	Dm
		112570 M9ND00_DROME (3-680): 3.38e-47: 184: 16.43		DYN_DROME (6-842): 0: 928: 66.23
+	Dm
		247616 O61618_DROME (3-680): 1.53e-43: 173: 15.79		DYN_DROME (6-842): 0: 928: 66.23
+	Dm
		91155 E3CTP7_DROME (10-209): 3.99e-30: 129: 43.27		DYN_DROME (6-842): 0: 928: 66.23
+	Ce
		760510 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		DYN1_CAEEL (3-823): 0: 899: 61.86