HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: RUFY4 (Q6ZNE9)
RUN and FYVE domain-containing protein 4
Gene: RUFY4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 571
+	Hs
		787926 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		RUN3A_HUMAN (15-380): 1.24e-64: 219: 16.62
+	Hs
		787860 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		EPS15_HUMAN (137-507): 1.48e-41: 162: 14.71
+	Mm
		787998 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		EPS15_MOUSE (137-493): 1.75e-36: 147: 15.00
+	Hs
		1302776 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		RUFY1_HUMAN (5-566): 2.32e-102: 326: 17.14
+	Hs
		61732 A6H8W8_HUMAN (6-845): 1.24e-62: 233: 14.86		EPS15_HUMAN (137-507): 1.48e-41: 162: 14.71
+	Hs
		787985 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		EPS15_HUMAN (137-507): 1.48e-41: 162: 14.71
+	Hs
		1078834 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		RUN3A_HUMAN (15-380): 1.24e-64: 219: 16.62
+	Hs
		787920 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		EPS15_HUMAN (137-507): 1.48e-41: 162: 14.71
+	Cl
		47357 F1PHV6_CANLF (2-476): 6.6e-38: 156: 14.91		A0A8I3PJA6_CANLF (137-507): 1.22e-40: 159: 14.17
+	Mm
		788010 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		EPS15_MOUSE (137-493): 1.75e-36: 147: 15.00
+	Hs
		1123895 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		RUN3A_HUMAN (15-380): 1.24e-64: 219: 16.62
+	Rn
		92844 ITSN1_RAT (11-737): 4.81e-34: 143: 12.14		E9PSY8_RAT (137-493): 2.66e-36: 146: 14.72
+	Hs
		1169516 MRCKB_HUMAN (223-886): 2.4e-41: 167: 12.72		FGD5_HUMAN (181-563): 5.32e-26: 115: 9.13
+	Hs
		787987 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		EPS15_HUMAN (137-507): 1.48e-41: 162: 14.71
+	Ce
		105845 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		G5ED80_CAEEL (181-563): 7.86e-26: 114: 11.31
+	Mm
		788002 EP15R_MOUSE (417-895): 9.06e-11: 67.9: 12.27		EPS15_MOUSE (137-493): 1.75e-36: 147: 15.00