HitPredict

Interactor 1: EPS15 (P42567)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: DAB2 (P98078)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Mitogen-responsive phosphoprotein)
Gene: DAB2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22648170
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001921 - positive regulation of receptor recycling GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0016324 - apical plasma membrane and 1 others more... GO:0030132 - clathrin coat of coated pit
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 897 Mm			1 766
+	Hs
		787894 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		DAB2_HUMAN (1-766): 8.87e-80: 273: 81.76
+	Hs
		787868 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		NUMB_HUMAN (26-678): 6e-47: 179: 14.24
+	Mm
		788008 EPS15_MOUSE (1-897): 1.37e-149: 465: 100.00		NUMB_MOUSE (26-678): 7.52e-45: 173: 13.19
+	Mm
		957141 EP15R_MOUSE (1-894): 3.1e-82: 286: 31.59		DAB2_MOUSE (1-766): 9.01e-96: 316: 100.00
+	Mm
		957157 ITSN1_MOUSE (2-537): 1.15e-36: 152: 12.50		DAB2_MOUSE (1-766): 9.01e-96: 316: 100.00
+	Mm
		1141842 EP15R_MOUSE (1-894): 3.1e-82: 286: 31.59		ANS1B_MOUSE (2-231): 5.14e-41: 164: 17.95
+	Hs
		957186 ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27		DAB2_HUMAN (1-766): 8.87e-80: 273: 81.76
+	Hs
		957209 REPS1_HUMAN (2-507): 1.29e-24: 112: 12.21		DAB2_HUMAN (1-766): 8.87e-80: 273: 81.76
+	Hs
		1264915 CTTB2_HUMAN (357-846): 1.74e-55: 211: 17.20		DP13A_HUMAN (20-242): 4.12e-37: 150: 12.45
+	Mm
		1206702 ITSN1_MOUSE (2-537): 1.15e-36: 152: 12.50		ANS1B_MOUSE (2-231): 5.14e-41: 164: 17.95
+	Hs
		269148 ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27		DAB1_HUMAN (11-617): 1.62e-37: 150: 23.57
+	Dm
		112569 M9ND00_DROME (1-493): 1.59e-34: 144: 10.95		NUMB_DROME (24-531): 1.64e-38: 153: 11.91
+	Hs
		833640 REPS1_HUMAN (2-507): 1.29e-24: 112: 12.21		NUMB_HUMAN (26-678): 6e-47: 179: 14.24
+	Hs
		833668 EP15R_HUMAN (417-861): 2.78e-17: 88.9: 12.92		NUMB_HUMAN (26-678): 6e-47: 179: 14.24
+	Ce
		60780 Q9U2T9_CAEEL (2-439): 1.16e-23: 109: 12.98		A5JYR4_CAEEL (5-289): 9.7e-38: 149: 28.91
+	Ce
		1353620 Q9U2T9_CAEEL (2-439): 1.16e-23: 109: 12.98		NUMB1_CAEEL (24-429): 3.32e-35: 143: 12.59
+	Ce
		283754 Q9U2T9_CAEEL (2-439): 1.16e-23: 109: 12.98		CED6_CAEEL (1-410): 3.55e-35: 142: 16.24
+	Dm
		91154 E3CTP7_DROME (474-790): 1.88e-10: 67: 11.49		NUMB_DROME (24-531): 1.64e-38: 153: 11.91
+	Dm
		561284 Q8T8W3_DROME (239-313): 1.9e-10: 66.2: 44.00		NUMB_DROME (24-531): 1.64e-38: 153: 11.91
+	Ce
		60778 Q8WSP1_CAEEL (218-313): 1.43e-09: 63.9: 40.63		A5JYR4_CAEEL (5-289): 9.7e-38: 149: 28.91