HitPredict

Interactor 1: EPS15 (P42567)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: PRKN (Q9WVS6)
E3 ubiquitin-protein ligase parkin (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase)
Gene: PRKN

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20064468
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043130 - ubiquitin binding GO:0045202 - synapse GO:0098794 - postsynapse and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 897 Mm			1 464
+	Hs
		226756 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		PRKN_HUMAN (1-464): 7.14e-141: 413: 83.66
+	Mm
		476700 EPS15_MOUSE (1-897): 1.37e-149: 465: 100.00		UBC_MOUSE (1-187): 2.64e-61: 214: 19.68
+	Hs
		475452 EPS15_HUMAN (1-897): 1.65e-159: 491: 87.65		UBC_HUMAN (1-77): 1.28e-33: 136: 31.17
+	Rn
		1126748 Q5JC29_RAT (1-776): 8.25e-128: 405: 94.33		UBC_RAT (1-180): 1.7e-60: 213: 20.44
+	Hs
		227694 FKB15_HUMAN (80-884): 4.86e-39: 159: 10.67		PRKN_HUMAN (1-464): 7.14e-141: 413: 83.66
+	Hs
		228313 REPS1_HUMAN (2-507): 1.29e-24: 112: 12.21		PRKN_HUMAN (1-464): 7.14e-141: 413: 83.66
+	Mm
		476822 EP15R_MOUSE (1-894): 3.1e-82: 286: 31.59		UBC_MOUSE (1-187): 2.64e-61: 214: 19.68
+	Hs
		228697 EHD1_HUMAN (17-102): 2.45e-15: 81.9: 33.72		PRKN_HUMAN (1-464): 7.14e-141: 413: 83.66
+	Rn
		88639 D3ZJR1_RAT (1-894): 3.94e-80: 280: 31.73		UBC_RAT (1-180): 1.7e-60: 213: 20.44
+	Hs
		228925 EHD3_HUMAN (12-102): 1.24e-14: 79.6: 28.57		PRKN_HUMAN (1-464): 7.14e-141: 413: 83.66
+	Hs
		228663 EHD4_HUMAN (213-318): 4.73e-12: 71.6: 39.62		PRKN_HUMAN (1-464): 7.14e-141: 413: 83.66
+	Mm
		477062 ITSN1_MOUSE (2-537): 1.15e-36: 152: 12.50		UBC_MOUSE (1-187): 2.64e-61: 214: 19.68
+	Mm
		70590 B2RR82_MOUSE (6-536): 3.81e-27: 121: 11.58		UBC_MOUSE (1-187): 2.64e-61: 214: 19.68
+	Hs
		475816 ITSN1_HUMAN (2-547): 1.98e-39: 160: 12.27		UBC_HUMAN (1-77): 1.28e-33: 136: 31.17
+	Hs
		475882 FKB15_HUMAN (80-884): 4.86e-39: 159: 10.67		UBC_HUMAN (1-77): 1.28e-33: 136: 31.17
+	Rn
		1144238 Q8R3Z7_RAT (213-318): 2.34e-12: 72.4: 39.62		UBC_RAT (1-180): 1.7e-60: 213: 20.44
+	Sc
		477280 END3_YEAST (15-377): 8.96e-15: 78.9: 17.51		UBI4P_YEAST (1-151): 4.3e-55: 189: 21.05
+	Sc
		477209 EDE1_YEAST (3-228): 4.49e-13: 75.8: 22.48		UBI4P_YEAST (1-151): 4.3e-55: 189: 21.05
+	Hs
		476483 ITSN2_HUMAN (6-552): 2.33e-26: 118: 11.31		UBC_HUMAN (1-77): 1.28e-33: 136: 31.17
+	Hs
		476502 EP15R_HUMAN (417-861): 2.78e-17: 88.9: 12.92		UBC_HUMAN (1-77): 1.28e-33: 136: 31.17