HitPredict

Interactor 1: AF9 (P42568)
Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
Gene: MLLT3

Interactor 2: AFF1 (P51825)
AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)
Gene: AFF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	21030982, 20431927, 20854876, 21896721, 21729782, 23260655
Identification Methods	affinity chromatography technology, nuclear magnetic resonance, circular dichroism, pull down, molecular sieving, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AF4_int~AHD
Common GO terms	GO:0008023 - transcription elongation factor complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 1210
+	Hs
		850806 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		AFF1_HUMAN (1-1210): 3.61e-130: 431: 100.00
+	Hs
		788073 AF9_HUMAN (1-568): 1.02e-96: 307: 100.00		AFF4_HUMAN (10-1208): 2.3e-90: 318: 34.44
+	Hs
		788016 AF9_HUMAN (1-568): 1.02e-96: 307: 100.00		AFF3_HUMAN (6-1207): 8.91e-78: 282: 28.25
+	Hs
		974525 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		AFF4_HUMAN (10-1208): 2.3e-90: 318: 34.44
+	Hs
		850830 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		AFF3_HUMAN (6-1207): 8.91e-78: 282: 28.25
+	Hs
		788041 AF9_HUMAN (1-568): 1.02e-96: 307: 100.00		NIPBL_HUMAN (12-1005): 1.12e-50: 199: 12.27
+	Hs
		1154038 NIPBL_HUMAN (139-558): 7.01e-62: 223: 16.94		NIPBL_HUMAN (12-1005): 1.12e-50: 199: 12.27
+	Dm
		113976 M9PB30_DROME (107-522): 8.83e-10: 64: 8.30		M9PB30_DROME (27-449): 7.87e-09: 62.8: 10.82