HitPredict

Interactor 1: AF9 (P42568)
Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
Gene: MLLT3

Interactor 2: AFF3 (P51826)
AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4)
Gene: AFF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	20431927, 20854876
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AF4_int~AHD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 1226
+	Hs
		850830 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		AFF3_HUMAN (1-1226): 3.22e-129: 429: 100.00
+	Hs
		788073 AF9_HUMAN (1-568): 1.02e-96: 307: 100.00		AFF4_HUMAN (22-1225): 1.06e-70: 260: 32.22
+	Hs
		788015 AF9_HUMAN (1-568): 1.02e-96: 307: 100.00		AFF1_HUMAN (16-1224): 1.32e-69: 257: 22.40
+	Hs
		974525 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		AFF4_HUMAN (22-1225): 1.06e-70: 260: 32.22
+	Hs
		850806 ENL_HUMAN (1-567): 1.44e-70: 238: 50.00		AFF1_HUMAN (16-1224): 1.32e-69: 257: 22.40
+	Hs
		788041 AF9_HUMAN (1-568): 1.02e-96: 307: 100.00		NIPBL_HUMAN (11-1063): 2.23e-46: 185: 11.07
+	Hs
		1154038 NIPBL_HUMAN (139-558): 7.01e-62: 223: 16.94		NIPBL_HUMAN (11-1063): 2.23e-46: 185: 11.07
+	Hs
		311785 YETS4_HUMAN (6-190): 1.98e-45: 161: 20.42		TACC2_HUMAN (110-1105): 3.89e-13: 76.7: 9.64
+	Dm
		113976 M9PB30_DROME (107-522): 8.83e-10: 64: 8.30		M9PB30_DROME (602-1169): 3.75e-11: 70.5: 6.33
+	Hs
		1264771 TITIN_HUMAN (145-514): 7.97e-09: 61.2: 10.86		TITIN_HUMAN (493-1062): 1.6e-09: 65: 8.42