HitPredict

Interactor 1: CASP3 (P42574)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Interactor 2: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	18723680, 19559631
Identification Methods	enzymatic study, protease assay
Interaction Type	direct interaction, protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 277 Hs			1 204
+	Mm
		936917 CASP3_MOUSE (1-277): 1.35e-141: 400: 86.64		GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06
+	Hs
		788166 CASP3_HUMAN (1-277): 2.23e-146: 412: 100.00		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Mm
		957032 CASP7_MOUSE (37-275): 4.8e-115: 334: 59.50		GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06
+	Hs
		854754 CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Hs
		854788 CASP8_HUMAN (25-275): 8.12e-93: 283: 35.32		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Hs
		854844 CASP7_HUMAN (2-275): 1.78e-114: 333: 50.35		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		667442 CASP1_HUMAN (2-276): 3.37e-78: 244: 26.26		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Hs
		854814 CASPA_HUMAN (36-230): 2.98e-72: 232: 34.65		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00